Abstract:
Introduction: Psoriasis is a common chronic inflammatory skin disease with unknown etiopathogenesis.
Aim: To examine the thiol/disulfide balance in psoriasis patients and to compare the results with a healthy control group.
Material and methods: Eighty patients with psoriasis and 80 healthy individuals who were age- and gender-matched with these patients were included in this study. Serum native thiol, disulfide and total thiol levels
were measured by a new automated method developed by Erel and Neselioglu. Disulphide/total thiol, disulphide/
native thiol and native thiol/total thiol were calculated.
Results: While there was no statistically significant difference in terms of disulphide levels (SS) between the patient and control groups (p > 0.05), there were significant differences in terms of total thiol and native thiol (SH)
levels, SS/SH, SS/total thiol and SH/total thiol ratios between the patient and control groups (p < 0.05). There was
a statistically significant relationship between duration of the disease and the disulfide/native thiol ratio (p > 0.05).
Conclusions: In recent years, there have been few studies on the role of oxidative stress in the etiopathogenesis
of psoriasis. In this study, we investigated in psoriasis patients, thiol/disulfide balance as a new oxidative stress
marker. The results were compared with a healthy control group. Our results showed that thiol/disulphide balance
shifted towards disulphide in psoriasis patients. This is important as a finding that supports the role of oxidative
stress in the pathogenesis of psoriasis.
