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Başlık: The frequency of laryngeal involvement in lipoid proteinosis patients
Yazarlar: Yükkaldıran, Ahmet
Aksoy, Mustafa
Yeşilova, Yavuz
Demir, Mahmut
İynen, İsmail
An, İsmail
Tanrıkulu, Osman
Anahtar kelimeler: Arytenoid; Larynx; Lipoid Proteinosis; Vocal Cord.
Yayın Tarihi: 2019
Yayıncı: Annals of Medical Research
Özet: Aim: Lipoid proteinosis (LP) is a rare autosomal recessive disorder that occurs with the accumulation of hyaline substance in oral cavity, laryngeal mucosa and skin. The aim of this study was to investigate the incidence of laryngeal involvement in patients with LP which have hoarseness and skin lesions, and the areas of hyaline substance accumulation in the larynx. Material and Methods: In this study, 21 patients who were admitted to our Dermatology outpatient clinic between January 2013 and December 2017 and diagnosed as LP with punch biopsy were evaluated. Laryngeal imaging was performed in otorhinolaryngology clinic, and the frequency of larynx involvement and the areas of hyaline accumulation in the larynx were evaluated. Results: Twenty-one patients with hoarseness and diagnosed by skin biopsy as LP were included in the study. Thickening of the vocal cords in 21 patients (100%); thickening and hypertrophic changes of arytenoids in 13 patients (61.9%); thickening and hypertrophic changes of the interarytenoid area in 10 patients (47.6%); thickeningand hypertrophic changes of epiglottis in 3 (14.3%) patients; hypertrophic changes and thickening of the aryepiglottic fold in 3 patients (14.3%); thickening and hypertrophic changes of ventricular folds in 2 patients (9.5%) were observed. Conclusion: In our study, similar to the data in the literature, the pathological changes were most frequently seen in the vocal cords and the least in the ventricle band, aryepiglottic fold and epiglottis. In order to better understand the laryngeal involvement and the areas of involvement in LP patients, studies with more patients are needed.
URI: http://hdl.handle.net/11513/257
Koleksiyonlarda Görünür:Dahili Tıp Bilimleri Bölümü

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