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http://hdl.handle.net/11513/226
Title: | Dynamic thiol/disulphide homeostasis in vitiligo patients |
Authors: | Aksoy, Mustafa Çelik, Hakim |
Keywords: | oxidative stress, thiol/disulphide homeostasis, vitiligo |
Issue Date: | 2018 |
Publisher: | Advances in Dermatology and Allergology |
Abstract: | Introduction: Vitiligo is an acquired depigmentation disorder with melanocyte destruction. Aim: To examine the thiol/disulphide balance in vitiligo patients and to compare the results with a healthy control group. Material and methods: Thirty-two patients with vitiligo and 35 healthy individuals were included in the study. Native thiol, disulfide and total thiol levels in plasma were evaluated using a new and automated spectrophotometric method. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol levels were measured. Results: There was no statistically significant difference between the two groups when the patient and control groups were compared in terms of thiol/disulphide balance (p > 0.05). There was no statistically significant difference in native thiol, disulphide and total thiol levels for vitiligo when compared with the control group (p > 0.005). Conclusions: In recent years, there have been numerous studies on the role of oxidative stress in the etiopathogenesis of vitiligo. In this study, we investigated in vitiligo patients whether thiol/disulphide balance is a new oxidative stress marker. The results were compared with a healthy control group. We measured the thiol/disulphide balance by a new method developed by Erel and Neselioglu. The serum thiol/disulphide levels were similar in the vitiligo patients and the control subjects, which indicated that the thiol/disulphide balance was not affected by vitiligo. We are of the opinion that new investigations to determine serum levels of thiol/disulphide may shed light on the possible roles of these molecules in vitiligo. |
URI: | http://hdl.handle.net/11513/226 |
Appears in Collections: | Dahili Tıp Bilimleri Bölümü |
Files in This Item:
File | Description | Size | Format | |
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21. Dynamic thioldisulphide homeostasis in vitiligo patients.pdf | 117.07 kB | Adobe PDF | View/Open |
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