Please use this identifier to cite or link to this item: http://hdl.handle.net/11513/182
Title: Thiol/disulphide balance in patients with psoriasis
Authors: Aksoy, Mustafa
Kirmit, Adnan
Keywords: disulphide, thiol, psoriasis
Issue Date: 2018
Publisher: Advances in Dermatology and Allergology
Abstract: Introduction: Psoriasis is a common chronic inflammatory skin disease with unknown etiopathogenesis. Aim: To examine the thiol/disulfide balance in psoriasis patients and to compare the results with a healthy control group. Material and methods: Eighty patients with psoriasis and 80 healthy individuals who were age- and gender-matched with these patients were included in this study. Serum native thiol, disulfide and total thiol levels were measured by a new automated method developed by Erel and Neselioglu. Disulphide/total thiol, disulphide/ native thiol and native thiol/total thiol were calculated. Results: While there was no statistically significant difference in terms of disulphide levels (SS) between the patient and control groups (p > 0.05), there were significant differences in terms of total thiol and native thiol (SH) levels, SS/SH, SS/total thiol and SH/total thiol ratios between the patient and control groups (p < 0.05). There was a statistically significant relationship between duration of the disease and the disulfide/native thiol ratio (p > 0.05). Conclusions: In recent years, there have been few studies on the role of oxidative stress in the etiopathogenesis of psoriasis. In this study, we investigated in psoriasis patients, thiol/disulfide balance as a new oxidative stress marker. The results were compared with a healthy control group. Our results showed that thiol/disulphide balance shifted towards disulphide in psoriasis patients. This is important as a finding that supports the role of oxidative stress in the pathogenesis of psoriasis.
URI: http://hdl.handle.net/11513/182
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