Please use this identifier to cite or link to this item: http://hdl.handle.net/11513/133
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dc.contributor.authorDikme, Reşat-
dc.contributor.authorPadak, Mahmut-
dc.contributor.authorGöz, Mustafa-
dc.contributor.authorAydın, Mehmet Salih-
dc.contributor.authorGöç, Ömer-
dc.date.accessioned2019-06-10T11:16:11Z-
dc.date.available2019-06-10T11:16:11Z-
dc.date.issued2019-
dc.identifier.otherDOI: 10.4328/ACAM. 20008-
dc.identifier.urihttp://hdl.handle.net/11513/133-
dc.description.abstractAs a result of natural immunity in the heart ST2 (IL1RL1) that protects the heart against excessive pressure load and tension, has two important isoforms (ST2L–membranebound, sST2-soluble). As ligand of ST2L and sST2 is interleukin 33 (IL33), the connection of ST2L to IL33 stimulates cardioprotective signal cascade whereas connection of sST2 to IL33 causes annihilation of these positive effects. As a high level of sST2 shows that the heart is under dense stress, this situation causes cell death, tissue fibrosis, decreased cardiac functions and an increase in progression rate of disease. That is why in cardiovascular disease sST2 is accepted as a biomarker of poor prognosis. It was obtained that the increase of sST2 over normal concentration multiplies negative situations related to cardiovascular diseases 3 times more. In 2013 in ACCF/AHA (American College of Cardiology Foundation/American Heart Association) guidelines, sST2 that was defined as “novel biomarker” for HF (Heart failure), is an independent biomarker from natriuretic peptides and cardiac troponins and is an important sign in cardiovascular diseases. ST2 is not affected by factors such as age, body mass index and kidney function disorder.en_US
dc.language.isoenen_US
dc.publisherThe Annals of Clinical and Analytical Medicineen_US
dc.subjectST2; Interleukin 1 Receptor-Like 1; sST2; Soluble sST2; Cardiovascular Diseases; IL1RL1en_US
dc.titleNew prognostic biomarker in cardiovascular field: ST2 (IL1RL1)en_US
dc.typeArticleen_US
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